I visited Prague with my grandparents while I was living with them during my internship in Amsterdam. They are veteran travelers and have been almost everywhere but they were nice enough to accompany me during my first trip here.
-Old Town Square (probably my favorite because there is so much to see in all of the little side streets as well as the main areas - this is also where the famous astrological clock is)
-The Prague Castle complex
-Josefov (this used to be the Jewish ghetto-it is much different than the main area of the city)
-Golden Lane (except it was super crowded and too tourist-y for my taste)
-The Dancing House
-The Lenin Wall
-Best dinner was at a local bar/pub off the main road where we had super amazing pork shoulder. Super. Amazing.